WHO highlights shortage of innovative antibiotics

The world is still failing to develop desperately-needed antibacterial treatments, despite the urgent threat of antibiotic resistance, according to a World Health Organisation report. None of the 43 antibiotics in clinical development sufficiently address drug resistance in the most dangerous bacteria. The majority offer limited clinical benefit over existing treatments, while 82% of recently-approved antibiotics are derivatives of older products with well-established drug-resistance.

WHO highlights 27 non-traditional antibacterial agents, ranging from antibodies to bacteriophages, and therapies that support the patient’s immune response and weaken the bacteria’s effect. However, while there are some promising products in development, only a fraction will make it to the market, owing to economic and scientific challenges. The low return on investment from successful products has limited the interest of major private investors and most large pharma players, and the small to medium-sized companies driving the pipeline often struggle to finance their products through to regulatory approval. 

Source: World Health Organization

Nicholas Hall Writes: “Just when you thought it was safe to go back in the water (to quote the movie “Jaws”), the World Health Organisation reminds us that there could be more and worse to come. The worldwide pharma industry has responded magnificently to Covid, and if a fraction of that effort went into the search for new antibiotics, we could perhaps avoid the next and possibly much worse pandemic, when superbugs attack mankind. I’m not referring to hacking from within the Dark Web, but bacteria for which existing antibiotics will be unable to cope! One medical expert has described this as making Covid look like a vicarage tea party!

To quote WHO: “Opportunities emerging from the Covid-19 pandemic must be seized to bring to the forefront the needs for sustainable investments in R&D of new and effective antibiotics … We need a global sustained effort including mechanisms for pooled funding and new and additional investments to meet the magnitude of the AMR (antimicrobial resistance) threat.” So I hope that Big Pharma will recycle the windfall from Covid vaccines into new antibiotic research, otherwise we will have many more years of lockdown!”

Immunity will be the focus of our next round of regional hot topic webinars, starting with a focus on Asia-Pacific on 19 May, followed by the Americas on 23 June and Europe on 21 July. Please contact elizabeth.bernos@NicholasHall.com to find out more about these upcoming sessions.

CCA down, but mental wellness products boom

Global CHC market sales in bricks & mortar outlets totalled US$150bn in 2020, with growth decelerating to 3.3%. Categories that were hardest hit by the slowdown were concentrated among CCA (notably cough and sore throat remedies) and Dermatologicals (such as lip care, cold sore and head lice treatments), as a result of social distancing guidelines. However, there were some notable sales successes in 2020, including sedatives & sleep aids and herbal memory & brain health supplements.

As we wrote in the latest issue of CHC.NewDirections: “Sleep quality has deteriorated as the Covid-19 pandemic has progressed, according to the ongoing University College London Covid-19 Social Study. Of the more than 70,000 participants, 12.7% reported “very good” sleep quality in March 2020 vs only 7.7% in March 2021. The number of people who said their sleep quality was “very poor” increased from 5.4% (Autumn 2020) to 10.1% at the start of the New Year.”

CIMA Market Analyst, Sacha Hawker, notes that this increase in sleep disturbance has been accompanied by a rise in sleep-related apps and devices in recent years, creating even more crossover between technology and consumer healthcare. And globally, there have been more than 160 new products with a mental wellness positioning since the pandemic began in December 2019 (Source: Nicholas Hall’s CHC New Products Tracker). With lockdown measures still in place alongside other stress factors, we expect this trend to continue.

Four notable 2020 sleep device launches from our Innovation in CHC report:
Withings Analyzer (Europe), SleepCheck (Australia), Sunrise (UK) and CoolDrift Versa (USA)

Commenting on the DB6 results, Nicholas Hall said: So there it is! Finally, the 2020 growth rate was somewhat lower than expected at 5% (all channels of distribution), more or less in line with the five years before the Covid outbreak. But within the market there has been radical change, and the stable overall growth rate cannot disguise the weakness of the cough & cold market – much worse than expected – and indeed of the whole retail sector. At the moment we are working on the short-term and long-term forecasts for the new edition of DB6, and there are puzzled frowns and long faces among the forecasting team.

So where do we look for rays of sunshine? As my colleague Celine Waller writes, anything connected with immunity and disinfection and e-Commerce is having a fine time, and the expectation is that this boom will carry over for two or three more years. And she points to sedatives & sleep aids among the rock stars with a 13% growth rate. This ties in perfectly with earlier predictions made during a webinar given by Jennifer Cooper and I a month ago. If you haven’t listened to the recording of that webinar, I strongly advise you to do so (link here).

Only two weeks to go until our European e-Conference 2021! Register now to explore e-Commerce and other major trends impacting CHC on 28-29 April with Nicholas Hall and a panel of industry experts.
For a look at the full agenda, please click here
To book your place at our European e-Conference, or to find out more about our other webinars, please contact Elizabeth.Bernos@NicholasHall.com 

Nasal sanitisers niche opens up post-Covid

One of the fast-emerging OTC niches in the CCA category is oral & nasal sanitisers, with several notable innovations in 2020 and 2021, including two more nasal sanitiser launches announced recently.

Australian-based Starpharma’s Viraleze nasal spray will become available online in the UK this week ahead of a retail rollout in April 2021, under an exclusive sales & distribution agreement with the retail chain, LloydsPharmacy (McKesson). This will be the product’s first appearance in Europe, although a regional launch is expected soon following its registration in the European Economic Area in February.

Comment from CHC Insight Managing Editor, Chris Allan: Viraleze contains the same antiviral ingredient (SPL7013 / astodrimer sodium) that features in Starpharma’s VivaGel products. Its powerful claim to deactivate “>99.9% of Sars-CoV-2 within one minute” is likely to attract wider media interest given the continuing national focus on the pandemic, and LloydsPharmacy has committed to “significant” marketing investment.

Separately, in Israel, SaNOtize has received interim approval to sell its nitric oxide nasal spray (NONS) in pharmacies. NONS protects users from viruses that enter the body through the upper nasal pathways. Local manufacturing under the brand name Enovid has begun in partnership with Nextar Chempharma Solutions and the spray is expected to appear on pharmacy shelves by the summer.

Meanwhile, in New Zealand the Ministry of Health denied claims by the Canadian-based biotech company that Enovid had been cleared for immediate OTC sale. Newshub quotes a MoH spokesperson: “Based on the therapeutic claims made for the product, its claimed mode of action and the nitric oxide ingredient, Enovid nasal spray would be a prescription medicine under New Zealand law (Medicines Act 1981) … Medsafe has received no applications for approval of this product for sale, supply or use in New Zealand.”

Comment: SaNOtize and Ashford & St Peter’s Hospitals NHS Foundation Trust in the UK recently announced results of clinical trials indicating that NONS represents a safe and effective antiviral treatment that could prevent the transmission of Covid-19, shorten its course and reduce the severity of symptoms and damage in those already infected.

Oral & nasal sanitisers is one of the delivery formats trends covered in our new Innovation in CHC 2021: NPD & Launch Activity under the Spotlight report. Seize the last chance to save GB£1,350 when you pre-order this forthcoming report before 31st March. To review the table of contents or pre-order your copy, please contact melissa.lee@NicholasHall.com

CBD industry revving up again in 2021

2020 was a tough year for the CBD industry, with Covid causing disruptions to supply chains as well as lower footfall in bricks & mortar retailers, and these setbacks were reflected in greater hesitancy from CBD marketers in terms of NPD activity – according to our CHC New Products Tracker service – with launch activity in 2020 much lower compared to 2019. However, recent regulatory developments in Australia and Mexico, and the uptick in M&A activity in the CBD industry over recent weeks, suggest 2021 will see a revival in NPD activity and sales.

For example, Curaleaf, a leading US provider of consumer cannabis products, last week signed a definitive agreement to acquire EMMAC, the largest vertically-integrated independent cannabis company in Europe, for around US$286mn. Curaleaf Executive Chairman, Boris Jordan, commented: “[This acquisition] provides an advanced base to reach scale within the nascent European cannabis market and transform Curaleaf into a truly international cannabis consumer packaged goods company. The consumer and political liberalisation trends around cannabis that are sweeping USA are also increasingly taking hold in Europe … The European cannabis market has the potential to exceed the US cannabis market over the long-term and will help fuel our growth for years to come.”

In addition, a wholly-owned subsidiary of British American Tobacco last week subscribed for around 58.3mn common shares – a 19.9% equity interest – of Organigram, a leading licensed cannabis producer, for C$221mn (US$176mn). The companies have also entered into a Product Development Collaboration Agreement, under which a Centre of Excellence will be established to focus on developing the next generation of cannabis products, with an initial focus on CBD. “The cannabis industry is still in the nascent stages of product development. We believe that product innovation backed by core fundamental R&D is necessary to establish a long-term competitive advantage in the cannabis industry,” said Organigram Chief Strategic Officer Paolo De Luca.

Another M&A CBD development from last week was MediPharm, a research-driven global leader in cannabis extraction, entering into a GMP white-label supply and contract manufacturing agreement with Cannim. The company has also commenced registrations for the launch of next-generation OTC products in Australia in 2021. Under the 3-year agreement, with options to extend, MediPharm will supply a full range of specially-formulated CBD and THC cannabis oil products, sold initially under Cannim’s Lumir brand. MediPharm will also provide Cannim with contract manufacturing options.

Finally, a bill that would legalise the recreational use of cannabis was approved in Mexico’s lower house of Congress last week and will move to the Senate for final approval. The legislation would enable users aged 18+ years with a permit to carry up to 28g of cannabis and grow up to eight plants at home for personal use. President Andres Manuel Lopez has argued that the bill could help to curb Mexico’s violent and powerful drug cartels. John Walsh, Director of Drug Policy for the Washington Office on Latin America, a US advocacy group, said: “Mexico, given its size and its worldwide reputation for being damaged by the drug war, to take this step is enormously significant. North America is heading towards legalisation.” Canada and Uruguay are the only countries in the world to have legalised cannabis for recreational use. With its liberal switch environment, Mexico could be an early adopter of OTC cannabis, possibly the second or third market after Australia.

Discover who the main CBD players are, and how big the market could get in our recent report, CBD 2020: The 20 Most Important Questions about CBD in the Future of CHC. To find out more, or to order your copy, please contact melissa.lee@NicholasHall.com.

NPD roundup: Women’s Health in 2020

To mark International Women’s Day, our blog this week rounds up some of the most notable women’s health NPD activity in the global CHC market in 2020, with examples from all four major regions (Europe, Asia-Pacific, North America and Latin America), as provided by our CHC New Products Tracker service.

Probiotics & prebiotics was a particularly lively source of women’s health innovation, including Farmoquimica’s late 2020 launch of Simbiofem in Brazil, positioned to balance female intestinal flora and claimed to be the first probiotic in the market for women’s health. In Spain, FertyPharma unveiled Fertybiotic Mujer Plus in early 2020, uniquely positioned to improve the fertility of women with PCOS (polycystic ovarian syndrome), while in South Korea Huons launched Elruby Menolacto Probiotics in Q4 2020, offering the benefit of an original formula to help support menopausal women. In the USA, a particularly innovative women’s health probiotic launch was HUM Private Party, with a unique formulation that combines a proprietary women’s probiotic blend with cranberry extract, which is positioned to support healthy vaginal and urinary tract health.

As for digital health solutions, which are profiled in one of the chapter’s of our upcoming Innovation in CHC report, a notable women’s health development in the UK was Velieve (Healthy.io), an at-home service for women to determine if they have a UTI (urinary tract infection). Velieve was test marketed in London first and is available as a kit (containing a urine collection cup, dipstick and colour board), which is delivered within 3 hours of ordering online, and the user is then required to download the Velieve app to guide them through the test, turning their smartphone into a medical device to read the dipstick.

Finally, looking at VMS, there were also several notable women’s health developments in China in 2020, including GSK’s extension of calcium supplement Caltrate with Caltrate Women, Unilever’s rollout of Olly The Perfect Women’s Multi and Eu Yan Sang’s launch of Gold Label Bak Foong Small Pills (a plant-based formula positioned as a treatment to alleviate menstrual pain).

Seize your last chance to save on our forthcoming report from Nicholas Hall’s CHC New Products Tracker, Innovation in CHC 2021. Putting innovation and NPD activity from 2020 under the microscope, click here to pre-order your copy without delay. For more information, or to place your order, please contact Melissa.Lee@NicholasHall.com

RB sales +11.8% in 2020; Biofreeze in, Scholl out

RB recorded its highest-ever sales increase in 2020, with net revenue up 11.8% on a like-for-like basis to £14bn (US$20bn). Health grew by 12.1% to £4.9bn (US$6.9bn), while Hygiene sales had an even better year (+19.5%) in 2020 and Nutrition sales were flat. E-Commerce sales grew by a record +56% in 2020 and now account for around 12% of group net revenue.

In Q4 2020, total RB net revenue was £3.6bn (US$5.1bn), +10.2%. Health grew by 2.8% to £1.2bn (US$1.7bn), with strong growth for Dettol, Durex and Gaviscon partially offset by the expected impact of the weak cough, cold & flu season, which resulted in the OTC portfolio being down just over 20% in the quarter. Hygiene (+25.7%) was even more the main growth driver for RB in Q4, while Nutrition sales were 3.5% lower, with excellent growth for Airborne and Neuriva offset by lower sales for Infant & Child Nutrition products in Greater China; a strategic review of the infant formula business in China, which represents 6% of group revenue, is underway. E-Commerce sales were up 50% in Q4, accounting for around 13% of total group revenue.

At the same time, RB announced it has entered into a definitive agreement to acquire the Biofreeze brand from US-based Performance Health (Madison Dearborn Partners). Financial terms were not disclosed. In USA, Biofreeze is the No.1 clinically-recommended topical pain relief brand and has delivered robust double-digit sales growth. “We see compelling opportunities to develop the topical pain relief category globally with Biofreeze and other RB pain management brands including Nurofen, Moov and Tempra,” said RB CEO Laxman Narasimhan. “The brand taps into the growing global trend for wellness and self-care and aligns with our strategy to build our US Health footprint into new spaces and places.” The deal is expected to close in Q2 2021.

In addition, US-based private equity group Yellow Wood Partners has agreed to acquire RB’s Scholl foot care brand, which operates globally outside of the Americas, for an undisclosed sum. The acquisition will reunite Scholl with the Dr Scholl’s brand – operated by Yellow Wood as a standalone company since its acquisition from Bayer in 2019 – as one entity after more than 30 years of separate ownership. The combined company, which generates annual retail sales in excess of US$700mn, with leading market shares in the global foot care category, will operate in 50+ countries. The deal is expected to be completed by Q3 2021.

Now is your final chance to register for our webinar on 3 March focusing on Mental Wellness across the Americas — join Nicholas Hall and Jennifer Cooper to explore the Sleep, Memory & Mood markets. For more information, or to take a look at the full schedule of webinars for 2021, please contact elizabeth.bernos@NicholasHall.com.

Sexual health OTC revolution

Building on the news covered in last week’s blog that Sanofi is planning to implement the US Rx-to-OTC switch of erectile dysfunction treatment Cialis by end-2024, this week we look at another major development in the OTC sexual health & fertility category – the announcement by the UK’s MHRA that it has launched a public consultation on the reclassification of two progestogen-only contraceptive pills containing desogestrel, marking the first time the agency has considered such a change.

MHRA is asking the public and stakeholders for their views on whether two continuous-use oral contraceptives – HRA Pharma’s Hana and Maxwellia’s Lovima, both as 75mcg film-coated tablets in 28-count packs – should become pharmacy medicines and available OTC, without a medical prescription (although, in parallel, desogestrel 75mcg will also remain available on prescription, with women potentially able to switch between prescription or pharmacy supply at different times). The agency notes that if the products are reclassified, pharmacists will have access to training materials and a checklist to help them to identify women who can receive the two medicines safely. Two separate consultations are open until 5th March (Hana link; Lovima link).

Following the switch of Adamed’s Maxon Forte (sildenafil 50mg) in Poland in early 2020, the rollout of OTC Viagra (Viatris) to Norway and Ireland in 2020, plus the EU centralised Rx-to-OTC switch of Fortacin (Recordati for Plethora Solutions) for premature ejaculation – formulated with lidocaine 150mg + prilocaine 50mg – in September 2020, the past year has seen a rapid expansion in the availability of OTC sexual health & fertility medicines. With OTC ED on the near horizon in the US market, the UK approval of the daily contraceptive pill as an OTC medicine could lead to a wave of similar approvals worldwide, and inject substantial growth into the global CHC market over the coming years.

CHC.NewDirections Consulting Editor, Nina Stimson adds: This really is an exciting proposal – not only a first for the UK, but also the first significant bid to offer oral contraceptives without prescription outside the Asia Pacific region – China and South East Asian markets lead the way, although sales in most markets are relatively small. If the proposal is approved, will UK pharmacists actively support the switch and help build OTC supply (and will the pharmacy protocol be sufficiently user-friendly not to push women back to the doctor)? And will any price differential between Rx or OTC supply be a factor? Not all ambitious switches in the UK have succeeded in the past, but we have high hopes for this one. Time will tell …

You can save up to GB£1,350 when you pre-order our forthcoming report from CHC New Products Tracker, Innovation in CHC: 2020’s NPD & Launch activity under the spotlight before 31st March! As well as looking in more depth at the latest OTC sexual health & fertility developments, the report also showcases the top 100 innovations in 2020 and features major ingredient trends, delivery format trends and much more. For more information, or to pre-order your copy, please contact melissa.lee@NicholasHall.com.

Sanofi CHC on track to be standalone unit by end-2022

At Sanofi’s Capital Markets Day 2021, the company’s Head of Consumer Healthcare, Julie Van Ongevalle, shared her vision for the business: “With the ongoing implementation of our fully integrated standalone model, we look forward to being more agile and reducing the complexity of our portfolio to drive growth with our consumer-centric, data-driven marketing approach.” The aim is to divest around 150 brands (from the current 250) in the next two years to focus on “priority categories”, such as allergy, body pain, general pain and mental wellness – particularly sleep aids – via a “granular approach”.

Rx-to-OTC switch has already been a key factor in driving growth in one of Sanofi’s priority categories, allergy remedies, thanks to the successful global OTC rollout of Allegra (first available in the USA in 2011) and launch of Xyzal Allergy 24HR (USA, 2017). Josephine Fubara, Chief Science Officer at Sanofi CHC, noted that Sanofi continues to make progress in bringing two potential OTC switches to the market in the coming years, erectile dysfunction treatment Cialis and flu antiviral Tamiflu, presenting a blockbuster opportunity with a combined sales potential of €1bn in the US market alone.

Source: Sanofi Capital Markets Day 2021 presentation

Sanofi also stated that it is on track with its plans to be a standalone CHC business by end-2022. The company said that the overall planning for the transition was complete, and that the majority of its standalone CHC legal entities would be operational by end-2021. Among the benefits that Sanofi believes this transition will bring include the agility to reignite its innovation engine and reduce time-to-market by around 20%.

Looking ahead, Sanofi is targeting above average market growth, driven by its focus on priority categories and Rx-to-OTC switch, with a view to becoming the best-in-market CHC performer by 2024-25. Supporting this objective will be a focus on consumer insights, an emphasis on e-Commerce and digital channels and the operational independence provided by Sanofi’s standalone model.

Save up to GB£1,350 when you pre-order our forthcoming report from CHC New Products Tracker, Innovation in CHC: 2020’s NPD & Launch activity under the spotlight before 31 March. The report showcases the Top 100 innovations in 2020 and features major ingredient trends, delivery format trends, and much more. For further details, or to pre-order your copy, please contact melissa.lee@NicholasHall.com.

Historically slow cough, cold & flu season

Now that four (P&G, J&J, GSK and Sanofi) of the world’s Top 6 consumer healthcare marketers have reported their latest quarterly results, two of the key takeaways are that 1) industry growth has proven very resilient in the face of the challenges posed by the pandemic, and 2) we are in the middle of an historically slow cough, cold & flu season in 2020-21, and CHC marketers with portfolios that skew heavily towards CCA products will continue to feel the impact of this trend on overall growth.

Figures from the WHO’s FluNet service show the quasi-total wipeout of flu at a global level. Despite some signs of very low levels of flu circulation in certain regions tracked by WHO, including Africa and the Western Pacific, the overall picture at a global level is stark, with an almost complete drop-off in global infections since Q1 2020. The data shown in the WHO chart below are provided remotely by National Influenza Centres (NICs) of the Global Influenza Surveillance and Response System (GISRS) and other national influenza reference laboratories collaborating actively with GISRS, or are uploaded from WHO regional databases.

Source: FluNet (www.who.int/flunet), GISRS

This trend is backed up by recent reports at a country level too. According to data obtained by The Times newspaper, UK flu cases are down by 95%; in the second week of January – the peak of the season – the number of reported influenza-like illnesses was 1.1 per 100,000 people vs a 5-year average rate of 27. This reflects similar trends in many other countries, including USA. While a billion people typically get flu globally each year, “much less than a tenth” of that figure will do so, according to leading expert John McCauley. There are a number of theories for the decline; lockdown restrictions, social distancing and the wearing of masks, and an increased focus on good hygiene practices have helped to prevent Covid, but also reduce the spread of other contagious illnesses. A major fall in international travel has curbed infections, while there has also been a huge take-up of the influenza vaccine. Meanwhile, some experts believe the spread of Sars-CoV-2 may have raised immunity against other viruses.

Nicholas Hall said: “Before Covid, we thought we knew the dynamics of consumer healthcare very well. I’ve given endless presentations quoting the three practical drivers of demand: Switch, the Emerging Markets and very importantly Cold & Flu pandemics. It’s fair to say that, without Covid, we would by now be lamenting a year of poor CHC sales. The actuality is that, with the exception of Voltaren Arthritis Pain and Differin in USA, there have been no significant switches in the past 3-4 years. The Emerging Markets still deliver, of course, but not at the stellar levels of the recent past; and we would by now be reading of the low impact on sales of the cough, cold & flu season.”

Explore the impact of lockdown on cases of cold & flu, and what the implications may be for CHC medicines, in our recently published Cough, Cold & Allergy report. For more information, or to order your copy, please contact melissa.lee@NicholasHall.com.

IRI: Top Product Claims, Retail Trends

New research by IRI points to some of the consumer retail trends that have emerged in the US market in the past year as a result of Covid. Looking at the entire CPG (consumer packaged goods) market in the USA, IRI’s recently published Leader Board report for 2020 highlighted some key trends, including consumers of all income levels driving more growth of premium and super-premium products, with health and wellness and self-care products experiencing higher demand. Among the fastest-growing categories in 2020, IRI listed home health care / kits (+172%), personal thermometers (+127%) and sleeping remedies (+28%).

The report also lists some of the marketers and categories that benefited from the strong shift to e-Commerce, including Vi-Jon (marketer of hand sanitiser Germ-X) and external analgesic rubs, as well as highlighting the leading product claims among both edible and non-edible consumer goods. As the chart below from the report indicates, “more vitamin C” was one of the fastest-growing claims in terms of sales (+24%) in the edible sector, while hemp seed oil (+110%), aromatherapy (+37%) and sleep health (+34%) were all in the Top 10 non-edible product claims in 2020.

Copyright: 2021 Information Resources Inc. (IRI).

Further IRI research found that small and extra-small CPG manufacturers’ and retailers’ own brands gained US market share vs larger players during 2020. Of the CPG industry’s US$933bn sales in measured channels in 2020, large manufacturers lost 1.3 share points (US$12.1bn in sales) to smaller players, owing to channel and category shifts and supply constraints. The CPG industry grew 10.3%, with smaller manufacturers (annual measured channel sales <US$1bn) capturing nearly one-third of that and private label products accounting for roughly 18%. This resulted in smaller manufacturers and PL gaining 1.1 and 0.2 share points, respectively, from larger manufacturers (measured channel sales exceeding US$5.5bn annually), which have lost market share in each of the past five years, but still represent 46.7% of total US sales in measured channels.

Comment from President of Strategic Analytics for IRI, Dr Krishnakumar Davey: The consumer shift towards smaller manufacturers and PL products is something that IRI has been documenting for several years, and we saw the trend accelerate during the pandemic. Many large manufacturers were not able to meet the surge in demand in Q2 when they lost most share to smaller players, who seized on this opportunity. Several brands attracted a number of new buyers as in-home consumption surged. Large manufacturers fared relatively better in Q3, but still lost significant share. Q4 saw some improvement and reversion to historical trends. Many extra-small manufacturers are mostly new entrants to the market into supply-constrained categories (e.g. soap, hand sanitisers, home healthcare kits). Small manufacturers playing in high-demand categories such as hygiene, personal care and health & wellness saw high growth.

Nicholas Hall will be joined online by experts from GSK, J&J and Convert Group during our European e-Conference 2021. Taking place on 28 & 29 April, there are options for individual passes or corporate licences. Take the chance to keep up with what’s happening in consumer healthcare today by contacting elizabeth.bernos@NicholasHall.com to reserve your space.